Overnight, Ms Clinton took part in a Townterview - a mix of a town hall and television interview - at the Newseum in Washington, DC.
In the event hosted by the ABC's Leigh Sales, Ms Clinton took questions beamed in via satellite from around the world, brushing off repeated encouragement to run for president in 2016.
"I am not thinking about anything like that right now," she said.
"I am looking forward to catching up on 20 years of sleep deprivation."
From Beirut, Ms Clinton was asked about her greatest unfulfilled ambition as secretary of state.
Obama has really relied on her in her position as secretary, just like he's relied on vice president Biden who's had a lot of strong successes and clear accomplishments in the last few months. And I think all this is consistent and a good foundation for whatever secretary Clinton decides to do next.
"Obviously I want to see peace in the Middle East and I want to see prosperity that includes all people and I want to see women and girls given their rights and opportunities," she said.
Referring to the recent gang rapes in India, Ms Clinton said: "There is still a tremendous amount of discrimination and outright abuse of women.
"When you put barriers in the way of half the population you in effect are putting breaks on your own development as a nation."
Ms Clinton also took a question from a person on a Chinese micro-blogging website, asking if competition between the United States and China would lead to both sides losing.
"The United States and China will together defy history," she said.
"Historically, a rising power and a dominant power have had clashes... but we want to see a rising power like China join the international community as a responsible stakeholder, continue its extraordinary efforts to lift hundreds of million of people out of poverty, create a strong vital middle class."
Amid the lighter moments, Australian comedians Hamish and Andy asked whether Ms Clinton wanted to be known as "the artist formerly known as secretary, or just Hill Clinton".
"I think we're going to have to work on that list," she replied.
Ms Clinton hands over to her successor John Kerry at the end of this week.
The US Senate today confirmed Senator Kerry as the next secretary of state, approving president Barack Obama's pick to replace Ms Clinton by a wide majority.
The Senate voted 94-3 in favour of Senator Kerry, after the chamber's Foreign Relations Committee approved the nomination earlier in the day.