Malala Yousufzai, 15, was shot in the head at point blank range in October as she left school in the Swat valley, in an attack that drew widespread international condemnation.
She was taken to Britain for treatment, and was discharged from the Queen Elizabeth Hospital in Birmingham earlier this month to spend time with her family after her initial treatment phase.
She will now return to hospital within the next 10 days to undergo surgery known as titanium cranioplasty to repair a missing area of her skull with a specially moulded titanium plate.
"This is, very simply speaking, putting a custom-made titanium plate over the deficit in her skull, primarily to offer physical protection to her brain in the same way as a normal skull would," the hospital's medical director Dave Rosser said.
Malala is completely deaf in her left ear after she was shot at point blank range in the October attack, so surgeons will also insert an electronic device into the ear that should help her hearing return to near-normal levels within 18 months.
Surgeons in Pakistan, who were the first to treat Malala before she was brought to Britain, inserted the missing section of her skull into her abdomen, but it had eventually been decided not to use the bone.
"The safest way to store that bone, to keep it sterile and healthy, is in the patient's body, so they will make an incision in the skin and tuck it into the abdomen," Mr Rosser said.
"Surgeons in consultation with Malala have decided that fitting this titanium plate is a better long-term procedure than trying to re-implant the bone after such a long period of time."
'Cheerful and determined'
Malala has become an internationally recognised symbol of resistance to the Taliban's efforts to deny women education and other rights.
More than 250,000 people have signed online petitions calling for her to be nominated for a Nobel Peace Prize for her activism.
Mr Rosser says Malala is a "remarkable young lady" and despite her ordeal she remains determined to continue speaking out for girls' right to education.
"She is very lively, she has a great sense of humour," he said.
"She is not naive at all about what happened to her and the situation she is looking forward to in terms of being a high-profile person, and potentially a high-profile target.
"But she remains incredibly cheerful, incredibly determined and incredibly determined to continue to speak for her cause."